Why Is pH Control Central to the Fermentation Process? A Comprehensive Guide
In industrial fermentation for biopharmaceutical production, process stability, batch-to-batch reproducibility, and high product yield are core quality control objectives.
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In industrial fermentation for biopharmaceutical production, process stability, batch-to-batch reproducibility, and high product yield are core quality control objectives.
Original Author: Sai'ao Jun | Cell Culture | May 19, 2026, 20:08 | Shanghai
In the biopharmaceutical industry, Chinese Hamster Ovary ( CHO ) cells serve as the core "cell factories" for the production of recombinant protein drugs, especially monoclonal antibodies.
Protein therapeutics (monoclonal antibodies, fusion proteins, ADCs, etc.) have become core treatments for major diseases like cancer and autoimmune disorders due to their precision targeting.
Extracellular vesicles (EVs) hold immense potential as drug delivery platforms due to their unique role in intercellular communication. However, numerous limitations—including low drug encapsulation efficiency and difficulties in scaling traditional methods—pose challenges for the clinical translation of EVs as delivery vehicles.
Given the sensitivity of animal cells, monitoring and controlling production process parameters is a mandatory task requiring meticulous attention. Monitoring must be systematically organized and should provide clear, unambiguous results.