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With the rapid advancement of life science technologies, gene and cell therapies are emerging as major areas of innovation in modern medicine. By regulating patient cell function, repairing or replacing defective genes, and utilizing engineered cells to deliver therapeutic effects, these advanced therapies offer new avenues for treating complex diseases that are difficult to manage effectively with traditional treatments.
Sodium hyaluronate (hyaluronic acid)—an essential raw material for skincare, dermal fillers, orthopedics, and ophthalmology—has long since moved beyond the era of scarcity when it was extracted from chicken combs and bovine eyes.
Many people new to fermentation have a misconception: the more data points displayed on a fermenter, the greater their control over the entire cultivation process. However, what truly determines the success or failure of the process is not the amount of data recorded by the system, but whether that data accurately reflects the actual state of the microbial culture. All online data initially comes from various sensors installed on the fermenter. These sensors detect physical and chemical parameters within the culture system; this data then passes through transmitters, data acquisition modules, and control systems to ultimately form the curves we see. Understanding these sensors involves more than just grasping their operating principles; it is even more important to know when they are prone to distortion, when they are prone to drift, and when they may mislead process decisions.
Stirring operations are applied across an extremely wide range of industries. Even within the biomanufacturing sector alone, beyond upstream fermentation and cell culture, stirring is extensively used in solution preparation, downstream purification, pre-harvest processing, formulation manufacturing, and environmental treatment.
In practical spray drying operations, collection efficiency is one of the core metrics for evaluating equipment performance and process compatibility. It is defined as the ratio of the mass of dry powder actually collected to the theoretical powder mass calculated from the total solid content of the feed liquid. For laboratory-scale spray dryers, the target collection efficiency is generally required to reach 85% to 95% or higher.
Optical pigments are a class of functional pigments with unique optical structures. Thanks to their colour-shifting properties, high gloss and excellent weather resistance, they are widely used in high-end cosmetics, automotive coatings, and printing and packaging. Their core value lies in the unique visual effects they produce through the refraction and reflection of light, whilst the dispersion state of the particles directly influences the product’s final optical performance and stability.
In industrial fermentation for biopharmaceutical production, process stability, batch-to-batch reproducibility, and high product yield are core quality control objectives.
Original Author: Sai'ao Jun | Cell Culture | May 19, 2026, 20:08 | Shanghai
In the biopharmaceutical industry, Chinese Hamster Ovary （ CHO ） cells serve as the core "cell factories" for the production of recombinant protein drugs, especially monoclonal antibodies.
Tangential flow filtration (TFF) perfusion technology utilising hollow-fibre modules offers significant advantages over other mammalian cell retention techniques. In recent years, a growing understanding of Starling flow has enabled filtration performance to be enhanced to levels comparable with, or even exceeding, those of alternative technologies.
Protein therapeutics (monoclonal antibodies, fusion proteins, ADCs, etc.) have become core treatments for major diseases like cancer and autoimmune disorders due to their precision targeting.
In biomanufacturing applications, fermenters and bioreactors play a central role in biochemical reactions, and the selection of valves for the associated piping systems is a critical factor in ensuring aseptic processes and controlling fluid conditions.
In the industrialisation of monoclonal antibody therapeutics, whilst upstream cell culture processes are continuously being upgraded and expression titers are constantly being improved, downstream purification processes have become the key bottleneck constraining mass production and regulatory compliance.
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