PFS2-10 Cell Perfusion Culture System

Cell perfusion culture is an efficient upstream cell culture technology for continuous bioproduct harvesting. Continuous supply of fresh culture medium and discharge of spent medium maintains high-density cell growth and stable cellular metabolism, effectively improving cell proliferation and overall biomanufacturing productivity.

The TFF perfusion system integrates advanced membrane filtration technology and automated control systems to deliver stable and scalable bioprocess performance. It supports single-use perfusion configurations for process development to small-scale bioproduction, compatible with bioreactor working volumes up to 50 L.

• Equipped with recirculation pump, feed pump, harvest pump and cell bleed pump. It features pressure monitoring, automatic TMP regulation and harvest-side sampling, requiring no extra auxiliary accessories.

• Compatible with multiple hollow fiber cartridges and matched tubing kits, covering cell culture scales ranging from 0.5 L to 50 L.

• Real-time tracking of critical bioprocess parameters including TMP and perfusion flow rate to maximize cell perfusion process stability.

• Standard configuration includes bioreactor weighing module and harvest weighing scale for precise control of culture volume and perfusion speed.

• Supports steady-state perfusion and dynamic CSPR (Cell Specific Perfusion Rate) perfusion modes, fulfilling diverse bioprocess intensification requirements.

• Compact benchtop footprint saves laboratory space and allows flexible deployment for various cell culture workflows.

• Low-shear magnetic levitation centrifugal pump reduces hydrodynamic stress and protects cell viability during long-term perfusion culture.

• Built with GMP-compliant control software to satisfy global regulatory standards for critical upstream biopharmaceutical manufacturing equipment.

• Biopharmaceutical Upstream Development & Pilot ManufacturingFed-batch and perfusion culture of CHO, HEK293 and mammalian cell lines for monoclonal antibodies, recombinant proteins, viral vectors and vaccine production.

• Process Intensification & Cell Culture Technology ResearchLaboratory study of high-density cell culture, CSPR strategy optimization, long-duration continuous cell culture and bioprocess parameter exploration.

• Synthetic Biology & Advanced Biotech R&DContinuous cultivation of engineered cell strains, dynamic metabolism research and screening of high-yield cell clones.

• Single-use Bioprocess Platform ValidationFeasibility test and process verification of disposable hollow fiber perfusion setups from lab scale to 50 L pilot bioreactors.

• Academic & University Life Science LaboratoriesTeaching and research for cell engineering, biochemical engineering, bioprocess engineering and perfusion culture technology.